Thalamus (dorsal thalamus)

External Features

  • Two ends (or poles)
    • Anterior
      • Narrow
      • Anteriorly: interventricular foramen.
      Posterior (Pulvinar)
      • broader
      • Inferior and medially: superior colliculus
      • separated from the geniculate bodies by the brachium of the superior colliculus.
  • Four surfaces
    • Superior
      • Lateral portion:
        • Thalamocaudate groove
          • Contains
            • A bundle of efferent nerve fibres from amygdala called the stria terminalis
            • Thalamostriate vein lie in this groove.
        • Body of caudate nucleus
        • Floor of the central part of the lateral ventricle formed by
          • The lateral part of superior surface of thalamus AND
          • The body of caudate nucleus
      • Medial portion
        • Separated from the ventricle by the fornix and by a fold of pia mater called the tela choroidea.
        •  
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      Inferior
      • Adjacent
        • Hypothalamus
        • Ventral thalamus
          • The ventral thalamus separates the thalamus from the tegmentum of the midbrain
      Medial
      • Forms the greater part of the lateral wall of the 3rd ventricle
      • Lined by ependyma
      • Interconnected by interthalamic adhesion: a mass of grey matter
      • inferior portion
        • is separated from the hypothalamus by the hypothalamic sulcus.
          • This sulcus runs from the interventricular foramen to the cerebral aqueduct
      • At the junction of the medial and superior surfaces of the thalamus,
        • Taenia thalami is present
          • The ependyma of the third ventricle is reflected from the lateral wall to the roof.
          • Underlying it there is a narrow bundle of fibres called the stria medullaris thalami (stria habenularis).
      Lateral
      • Adjacent to internal capsule, which separates it from the lentiform nucleus

Internal structure

Consist of mainly grey matter and a small amount of white matter:
  • White Matter
    • Outer surface
      • Superiorly: covered by Strarum zonale: a thin layer of white matter
      • Laterally: external medullary lamina: a thin layer of white matter
      • Of note: medially it is covered by the ependyma of 3rd ventricle
      Internally a ‘Y’ shaped bundle of white matter called internal medullary lamina divides the grey matter of thalamus into three major groups of nuclei:
      • anterior group
      • medial group
      • lateral group
  • Grey Matter
    • Main thalamic nuclei
      • Sensation from the face is received by which thalamic nucleus?
        • Ventroposteromedial (VPM) nucleus.
        • Ventroposterolateral (VPL) nucleus receives sensory input from the body
       
      Other Thalamic Nuclei
      • Intralaminar nuclei
        • Embedded within the internal medullary lamina.
        • There are several nuclei in this group.
          • Centromedian nucleus
            • Most important
          • Parafascicular nuclei
          • Rostral intralaminar nuclei
      • Midline nuclei
        • consist of scattered cells that lie between the medial part of the thalamus and the ependyma of the third ventricle.
      • Medial and lateral geniculate bodies (aka metathalamus)
      graph LR A[Thalamus] --> B[Anterior] A --> C[Medial] A --> D[Lateral] B --> B1[Anterior nucleus] C --> C1[Medial dorsal nucleus] D --> D1[Dorsal group] D --> D2[Ventral group] D1 --> D1a[Lateral dorsal] D1 --> D1b[Lateral posterior] D1 --> D1c[Pulvinar] D2 --> D2a[Ventral anterior nucleus] D2 --> D2b[Ventral lateral nucleus] D2 --> D2c[Ventral posterior nucleus] D2c --> D2c1[Ventral posteromedial nucleus] D2c --> D2c2[Ventral posterolateral nucleus]
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Connections of Thalamus

General
  • The thalamus is the gateway to the cerebral cortex: all major sensory pathways, except olfactory, relay in the thalamus before ascending to the cortex.
Afferent
  • From subcortical centres converge on the thalamus
    • Type of impulse
      From
      Through
      To
      Exteroceptive impulses and proprioceptive impulses
      Medial lemniscus, Spinothalamic tracts Trigeminothalamic tract.
      Cerebellum, Cortex
      Visual impulses
      Retina
      Optic tract
      Lateral geniculate bodies
      Auditory impulses
      Cochlear
      CN8 → lateral lemniscus/inferior colliculus
      Medial geniculate bodies
      Sensations of taste
      Tongue
      CN12 → Solitariothalamic fibres
      Primary somatosensory cortex.
      Olfactory impulses
      Nasal mucosa
      CN1 → Indirectly through amygdaloid complex (thalamus does not receive direct olfactory impulses)
      Anterior olfactory nucleus, Piriformis cortex
      Visceral information
      Reticular formation from the hypothalamus
       
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      Diagram to show areas of superolateral and medial surfaces of cerebral cortex that are connected to individual thalamic nuclei. The connections are reciprpcal.
      Diagram to show areas of superolateral and medial surfaces of cerebral cortex that are connected to individual thalamic nuclei. The connections are reciprpcal.
  • From all parts of the cerebral cortex, the cerebellum, and the corpus striatum.
Efferent
Cerebral cortex
  • Thalamocortical projections/radiations
    • Form large bundles that are described as thalamic radiations/ thalamic peduncles
      • Anterior (or frontal)
        • Anterior nucleus and medial nucleus → frontal lobe
      • Superior (or dorsal)
        • Sensory motor → precentral and post central gyri
      • Posterior (or caudal)
        • Visual → calcarine cortex
      • Inferior (or ventral)
        • Auditory → heschl gyrus
Others
  • Corpus striatum
  • Hypothalamus
  • Reticular formation
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