Neurosurgery notes/Anatomy/Embryology/Cranial nerve development

Cranial nerve development

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  • The cranial sensory (afferent) and parasympathetic (visceral efferent) ganglia appear during the end of the 4th week and the beginning of the 5th week.
    • Neurons in the cranial nerve sensory ganglia have a dual origin.
      • Neural crest cells/Ectodermal placodes
        • Nasal placodes
          • The nasal placodes give rise to the primary neurosensory cells of the olfactory epithelium, and the axons of these cells form the olfactory nerve (I), which penetrates the olfactory bulb of the telencephalon.
          • With some exceptions, the remaining cranial nerve sensory ganglia show a regular stratification with respect to their origin: the ganglia that lie closer to the brain (proximal) are derived from neural crest cells, whereas the neurons of ganglia lying farther from the brain (distal ganglia) are formed by placode-derived cells.
        • Retinal placodes
        • Otic placodes
      • Epipharyngeal placodes
        • The sensory ganglia associated with the second, third, fourth, and sixth pharyngeal arches are derived from the corresponding epipharyngeal placodes and from neural crest cells.
        • Each of these nerves has both a
          • Proximal sensory ganglion (e.g., superior ganglion of IX)
          • Distal sensory ganglion (e.g., superior ganglion of IX).
  • Pharyngeal arches
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Arch
Nerve
Artery
Muscle
Bone
1st (Mandibular)
V2 and V3
Maxillary, ECA
Mastication
Anterior belly of digastric Mylohyoid
Tensor tympani
Tensor veli palatini
Maxilla, mandible, zygoma, temporal bone, incus, malleus, Meckel's cartilage, sphenomandibular ligament
2nd (Hyoid)
VII
Stapedial, hyoid
Muscles of facial expression
Buccinator
Platysma
Stapedius
Stylohyoid
Posterior belly of digastric
Auricular
Stapes, temporal styloid process, lesser horn and upper body of hyoid, stylohyoid ligament, Reichert's cartilage
3rd
IX
CC/ICA
Stylopharyngeus
Greater horn and lesser body of hyoid, thymus, inferior parathyroids
4th
X, superior laryngeal
Right: subclavian
Left: aortic arch
Cricothyroid
Intrinsic muscle of soft palate (except tensor veli palatine)
Thyroid cartilage, superior parathyroids, epiglottic cartilage
6th
X, recurrent laryngeal
Right: pulmonary
Left: pulmonary and ductus arteriosus
Intrinsic muscle of larynx (except cricothyroid)
Cricoid cartilage, arytenoid cartilage, corniculate cartilage, cuneiform cartilage