Neuromuscular Junctions

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General

  • The site where the nerve ending comes into intimate contact with the muscle fibre
  • Axon terminals are lodged in grooves in the sarcolemma covering the sole plate
  • Acetylcholine is released

Facts about muscle action

  • All or none law: When a stimulus above the threshold strength is applied, the muscle (and the motor unit, innervated by a single axon) contracts to its full extent.
  • Fatigue: Depletion of neurotransmitter causes failure of muscle to contract.
  • Muscle tone: Some fibres, in a resting muscle, are always in a state of contraction.
  • Endurance: The capacity of a muscle to maintain activity over a period of time.
  • Trophic effect: Nerve supply maintains the integrity of the muscle