Afferent visual system
- The axons become myelinated after passing through openings in the sclera called the lamina cribrosa.
- Retrobulbar optic nerve has three segments: intraorbital, intracanalicular in the optic canal, and intracranial just anterior to the optic chiasm
- At the optic chiasm, more than half of the optic nerve axons decussate.
- The retrochiasmal pathway consists of the optic tract, the lateral geniculate nuclei where the retinal ganglion cell axons synapse, the geniculocalcarine tracts in the temporal and parietal lobes, and the striate cortex in the occipital lobe.
Normal human visual field (for each eye)
- Blind spot:
- Due to absence of light receptors in the optic disc due to penetration of the retina by the optic nerve and vessels
- Temporal side of the macular visual area
- Normal visual field
- In degrees from the central point is 60 degrees nasal, 50 degrees superiorly, and 90-100 degrees temporally
- The nasal and temporal hemifields in each eye overlap but the monocular temporal crescent has no perimetric correlate in the fellow eye because the temporal visual field is larger than the nasal visual field, hence there are more crossing nasal fibers than there are ipsilateral temporal fibers with a 53:47 ratio.
- The extra nasal fibers that cross accounts for the non-overlapping contralateral temporal crescent.
- These fibers end up in the most anterior medial striate cortex and compromise 8-10% of the striate cortex.
- This monocular representation in a retrochiasmal pathology is attributed to the monocular innervation in that area.
- Thus, 30-40 degrees of the peripheral temporal visual field is unpaired and has unilateral representation in the contralateral visual cortex. Damage to this area of the visual cortex leads to the contralateral temporal crescent
Visual field testing
- Confrontation
- Do 4 quadrants with colour as a fast check
- Do blind spot check with red pin as blind spot increases with papillodema
- Absolute and relative scotoma
- Red hat pin
- Relative scotoma
- Magnocellular pathways
- White hat pin
- Absolute scotoma
- Parvocellular pathways
- By perimetry with a tangent screen
- Use the small red stimulus since desaturation of colour is an early sign of chiasmal compression
- Types
- 160 degree testing
- HVF requires good patient cooperation to be valid
- False negative: asleep
- False positive: trigger happy
- Central 60 degree
- Has SD results
Goldman perimetry
The blind spot is incoorporated into the Superior temporal and nasal quadranopia.
Together with the right eye. The patient has a Right homonymous heminanopia that is incongruent (i.e. one is upper and one is lower quadrant)
Blue line is the outer isomere.
The 3 lines have different light intensity and light size.
This image is of the right eye visual field as the n shaped blind spot is on the temporal side (the right side here)
Automated Humphrey perimeter
See Pituitary eye assessment
- Estermann driving standards
Macular
- Macular sparing in occipital cortex lesions is due to the dual blood supply from middle cerebral and posterior cerebral arteries to the occipital poles.
- Sparing/splitting
- Macular splitting: Lesions anterior or at/just posterior to the LGB, optic tract/radiation
- Macular sparing: Lesions posterior to the LGB, primarily occipital cortex
- Reasons for macula sparing in a PCA stroke causing homonymous heminanopia
- Visual cortex has a dual blood supply, from the middle (MCA) and posterior (PCA) cerebral arteries or the posterior temporal and calcarine arteries.
- Macula projects to two hemispheres hence
Knee of Von willie brand - Junctional scotoma
- Central scotoma ipsilateral eye
- Superior temporal quadranopia in contralateral eye/total vision loss in contralateral eye
Lateral geniculate nucleus
Optic radiations (geniculocalcarine tract)
- Formed by axons from neurons of
- Lateral geniculate body and
- Pulvinar of the thalamus
- Is part of the sub and retrolenticular component of the internal capsule.
- Course
- Forms part of the posterior thalamic peduncle;
- Passes under the lentiform nucleus as fibres of the sublenticular part of the internal capsule,
- Above the stria terminalis and the tail of the caudate nucleus; and
- Joins the sagittal stratum that forms the lateral ventricular wall.
- Relation
- Located within middle and superior temporal gyri, and always above the inferior temporal sulcus
- The mean distance between the cortical surface of the middle temporal gyrus and the lateral edge of the optic radiation was 21 mm
- Forms part of the roof and lateral wall of the temporal horn
- Terminate at the calcarine cortex (Brodmann area 17) within the superior and inferior lips of the calcarine fissure
- Average length was 95mm
- 3 parts
- Course
- Follows an anterolateral direction along the roof of the temporal horn, lateral to the amygdala and perpendicular to the anterior commissure.
- Anterior to the temporal horn, the fibres shift backward, forming the Meyer loop, assuming a posterolateral course, hence becoming lateral to the temporal horn and to the atrium, and ending along the inferior lip of the calcarine fissure
- Extends up to the tip of the temporal horn
- Of note:
- Amygdala forms the anterior wall of the temporal horn
- Hippocampus forms the floor of the temporal horn
- Most vulnerable part of the optic radiation when approaching the temporal horn and the temporomedial region.
- Damage results in superior homonymous quadrantanopic visual field deficits,
- Occurs in 50% to 90% of cases after anterior temporal lobectomies
- Measurements
- Course:
- Lateral direction crossing superiorly the roof of the temporal horn and then turns sharply, following a posterior course lateral to the atrium and to the occipital horn, passing above and through the inferior longitudinal fasciculus, and ending at the lateral aspect of the occipital pole.
- Relations
- Anterior third of central bundle covers the auditory radiation,
- Medially: Tapetum (Medial to tapetum is the ependyma of ventricle)
- Measurements
- Lateral geniculate body ↔ the central bundle: 17.4 mm
- Course: posteriorly, forming the lateral wall and part of the roof of the atrium and occipital horn, ending along the superior lip of the calcarine fissure.
Anterior bundle (meyer loop)
Point A | Point B | Distance (mm) |
Ambient gyrus (uncus) | Meyer loop | 22 |
Temporal pole | anterior edge of the Meyer loop | 28.4 (20-33) |
Anterior border of Meyer loop • Meyer loop is anterior to temporal horn • At this level, the anterior commissure fibres (of the occipital extension) were found to be intermingled with the optic radiation fibres. | Temporal horn | 4.5 (2-7) |
Limen insulae | Meyer loop (anterior bundle) | 10.7 (7-13) |
Anterior edge of Meyer loop | Lateral geniculate body | 21 (18-28) |
Central bundle
Posterior bundle (baum's loop)
Visual cortex
Striate cortex
- Visual processing involves signal relay from the retina via the lateral geniculate nucleus to the striate cortex (area V1/primary visual cortex/calcarine cortex/Brodmann area 17).
- Has strong retinotopic localisation, such that striate occipital lesions cause deficits restricted to segments of the visual field.
- Primary visual cortex (V1/Area 17)
- Sup: Cuneus gyrus
- Calcarine fissure
- Inf: lingual gyrus
- The band/line of Gennari
- Myelinated fibres of optic radiation that enter the visual cortex on the layer 4
- Gives the striated appearance of the visual cortex on myelin staining
- Occipital (striate) cortex has dominance columns, except in
- The region where the blind spot is located.
- The cortical region representing the monocular temporal crescent of both eyes
Extra-striate cortex (Association cortexes)
- Located in Brodmann areas 18/19 at occipital lobe
- Organised more by process than by visual field location
- Different areas of extrastriate cortex are involved in colour, motion perception, etc:
- Defects
- Deficits in certain aspects of vision:
- Perception of motion, affecting the entire visual field.
- Comprised of
- V2
- V3
- Selective for orientation.
- V4
- V5 (MT: Middle temporal)
- Function
- Integrating visual information
Location of optic radiation in relation to atrium and tapetum
- The optic radiations does not cover the superior 1/3 of the atrium
- The optic radiations overlies the tapetum of the corpus callosum
- The tapetum also overlies the atrium of the lateral ventricles
- Both the optic radiations and tapetum form the lateral wall of the atrium and occipital horn of the lateral ventricles
General
- Retina → Optic nerve → Optic chiasm → Optic Tract → Lateral geniculate body → optic radiation → Calcarine cortex
Retina
- Rod/cone (photoreceptors) → Bipolar cells (primary sensory neurons) → ganglion cells (secondary sensory neurons)
- Ganglion cell types
- Classes XYW system
- 3 locations that the cells response to
- Pretectum: pupillary reaction (light reflex)
- LGN: conscious vision-cortical visual processing
- Superior colliculus: eye movement
Cell type | Function | Response type | Transmission rate | Cell body |
X cells | 80% analysis of detail and colour | Tonic response to: pretectum, LGN | Slow | Largest |
Y cells | Motion detection | Phasic response to: LGN, Superior colliculus | Rapid | |
W cells | Project to brainstem | Tonic and phasic response to superior colliculus, pretectum | Very slow | Smallest |
- Receptive fields
Optic nerve
- Made up of: Ganglion cell axons + Glia cells
Lateral geniculate body
- Most fibres from optic tract reach LGB some end up in
- Pulvinar
- Pretectal nucleus
- Superior colliculi
- Has 6 layers
- Magnocellular (large cell) layers:
- Layers 1,2
- Movements and location
- Parvocellular (small cell) layers:
- Layers 3-6
- Colour and detailed forms
- Contralateral nasal hemiretina project to layers 1,4,6
- Ipsilateral nasal hemiretina project to layers 2,3,5
- Do not overlap
- Exit the LGN as optic radiations
- Magnocellular pathway (ventral)
- Parvocellular pathway (dorsal)
- Here they still contain the on and off center and surround visual processing like the bipolar cells
Pathology
- Diseases of the afferent visual system
- Compressive and Infiltrative Optic Neuropathies
- Compression: Classified by location
- Intra-orbit
- Thyroid eye disease
- Optic nerve sheath meningioma
- In optic canal
- Meningioma in the optic canal
- Intracranial
- Sphenoid wing meningiomas
- Pituitary adenomas
- Opthalmic artery aneurysms
- Causes slow progressive vision loss