Neuropatch
- Manufacturer: BBraun
- Fine fibred microporous fleece manufactured from a highly purified polyesterurethane.
- The fine fibred microstructure supports the rapid infiltration of connective tissue cells.
- Pros
- High liquid tightness of the implant prevents CSF leakages
- Tissue tolerant
- High tensile strength of the implant prevents suture pull out
- Good suturability
- Adaptable to anatomical structures
TissuDura
- Baxter
- Colloidal collagen from equine Achilles tendon and is inactivated with sodium hydroxide and chloriduric acid.
DuraGuard
- Bovine pericardium cross linked with gluteraldehyde
TissuePatchDural™ Sealant Film
- Is a self-adhesive film used to seal and reinforce against fluid (including CSF) and/or blood leakage, where repair of the dura mater is required
- It is comprised of TissueBond™ a patented polymer technology.
- This technology is based on the in-situ bonding of synthetic polymers to bodily tissues
- The products are thin, synthetic films which bond covalently to amine groups on the surface of internal tissues to provide a watertight seal
Duraseal
- Manufacturer: Integra life sciences
- A synthetic, absorbable polyethylene glycol (PEG) hydrogel
- Goal
- To prevent CSF leak
- CONTRAINDICATIONS:
- Do not apply the DuraSeal® hydrogel to confined bony structures where nerves are present since neural compression may result due to hydrogel swelling. The hydrogel may swell up to 50% of its size in any direction.
TISSEEL glue
- Fibrin sealant
- Made from (pooled human plasma which can contain infectious agents
- Human fibrinogen
- Thrombin
- Aprotinin
- A protein known to be associated with anaphylactic reactions
- Stops plasminogen from activating → prevents premature clot degradation
- Mechanism of action
- Note
- Is denatured when exposed to solutions containing alcohol, iodine or heavy metals.
- Does not expand
- Manufacturer
- Baxter
- Goal
- Hemostasis:
- A fibrin sealant indicated for use as an adjunct to hemostasis in adult and pediatric patients (>1 month of age)
- Tisseel is effective in heparinized patients.
- Sealing:
- A fibrin sealant indicated as an adjunct to standard surgical techniques (such as suture and ligature) to prevent leakage from colonic anastomoses following the reversal of temporary colostomies.
- Contraindication
- Allergic to Aprotinin
Adherus
- Manufacturer
- Stryker
- Contains:
- Activated polyethylene glycol (PEG) ester powder and
- Polyethyleneimine (PEI)
- For use in patients who are 13 years of age and older
- CI
- Should not be used in confined anatomical spaces where nerve compression is of concern.
- The hydrogel may swell by up to 13% of its size in any dimension or 46% by volume after application
Types of seal
Product | Components | Contraindications | Manufacturer |
Tissucol | Human fibrinogen, thrombin, albumin, and animal aprotinin | Not specified in the available resources. | Baxter |
Tisseel | Fibrinogen and Thrombin aprotinin | - Must not be used for massive or brisk arterial bleeding - Must not be injected directly into the circulatory system - Must not be used in individuals known to have anaphylactic or severe systemic reaction to human blood products | Baxter |
Evicel | Fibrinogen and Thrombin | - Must not be used for the treatment of severe or brisk arterial bleeding - Must not be injected directly into the circulatory system. - Must not be used in individuals known to have anaphylactic or severe systemic reaction to human blood products. | Johnson & Johnson Medical |
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