- (Phycomycosis)
- Usually occurs in diabetics
- Organism: Mucor and Rhizopus spp.
- It has nonseptate right-angle branching hyphae.
- Fungus is from the soil.
- Nonseptate right-angle branching hyphae
- Rhinocerebral involvement is most common in
- Diabetic patients with acidosis
- Dehydrated children with diarrhoea
- Immunosuppression who develop acidosis.
- Mechanism
- Inhalation of spore → fungi grows in the wall of the blood vessels of sinuses →
- Direct extension from sinuses through cribriform plate → brain
- Spread through orbital veins → cavernous sinus → brain
- Presentation
- It causes periorbital swelling, proptosis, and nasal discharge.
- Frontal lobe abscess
- Cavernous sinus thrombosis
- Headache
- Facial pain
- Black necrotic Escher on face
- Cranial nerve involvement
- Treatment is with amphotericin B.
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