MAST-PROPHYLAXIS
- Compares different anti-epileptic treatments in the prevention of seizures.
- Inclusion
- Patients aged ≥10 years,
- TBI
- Managed in an NSU
- Without an acute symptomatic seizure
- Patient or Legal Representative is willing and able to provide informed consent or in the absence of a legal representative, an Independent Healthcare Professional provides authorisation for patient randomisation within 48 hours of admittance.
- Exclusion
- Post-traumatic seizures
- Unsurvivable injury
- Previous history of epilepsy
- Patients who are taking an AED pre-TBI
- Pregnancy or breastfeeding
- Any known hypersensitivity to study drugs (or hydantoins or pyrrolidone derivatives) or any of its excipients
- Time interval from the time of admission to NSU to randomisation exceeds 48 hours
MAST-DURATION
- Compares a short course and a long course of anti-epileptic treatment in the treatment of seizures.
- Inclusion
- Patients aged ≥10 years
- TBI managed in an NSU
- Patient started on an phenytoin or levetiracetam due to an acute symptomatic seizure during acute hospitalisation
- Patient or Legal Representative is willing and able to provide informed consent or in the absence of a legal representative, an Independent Healthcare Professional provides authorisation for patient enrolment
- Exclusion
- Unsurvivable injury
- Previous history of epilepsy
- Patients who are taking an AED pre-TBI
- Patient who has been clinically prescribed an AED to treat PTS (other than phenytoin or levetiracetam since current admission
- Any known hypersensitivity to study drug selected or any of its excipients
- For phenytoin: known hypersensitivity to other hydantoins
- For levetiracetam: known hypersensitivity to other pyrrolidone derivatives
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