- The Bohr effect is a shift of the dissociation curve to the right, signifying a reduction of the oxygen affinity of the haemoglobin molecule and thus a greater tendency to off-load oxygen into the tissues (i.e. in acute or chronically under perfused tissue).
- And Pregnancy (fetal Hb has higher O₂ affinity than adult Hb because of decreased affinity for 2,3‑BPG, causing a left shift and promoting O₂ transfer across the placenta to the fetus).
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