Acquired autoimmune demyelinating motor neuropathy lacking the ascending features of GBS, or the radiculoneuropathy of CIDP.
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- These patients are usually younger to middle-aged men who develop focal arm weakness in the distribution of a named nerve relatively suddenly, with additional named motor nerves becoming involved over months/years in an asymmetric fashion such that it may resemble motor neurone disease (MND). In this case, the nerves involved are the left radial nerve, right ulnar nerve, and right common perineal nerve.
However, unlike MND there are no upper motor neuron symptoms and nerve conduction studies demonstrate a demyelinating picture (multifocal conduction block, temporal dispersion, decreased velocities, delayed/absent F waves) rather than an axonopathy, and anti-GM1 antibodies frequently raised. MMN is a demyelinating condition just like acute inflammatory demyelinating polyneuropathy (Guillain-Barré syndrome) or chronic inflammatory demyelinating polyneuropathy (CIDP), all of which therefore respond to intravenous immunoglobulin (IVIG).
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