- Function
- Component of coenzyme A (CoA, a cofactor for acyl transfers) and fatty acid synthase.
- Deficiency
- Dermatitis, enteritis, alopecia, adrenal insufficiency may lead to burning sensation of feet ("burning feet syndrome"; distal paresthesias, dysesthesia).
- Immediate precursor to co-enzyme A and phosphopantetheine that is involved in fatty acid metabolism. Acetyl-CoA is necessary for the synthesis of the complex fatty-acyl chains of myelin → Affect myelination of nerve → when loss can cause dysethesia and paresthesia
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