- Function
- Converted to pyridoxal phosphate (PLP), a cofactor used in transamination (e.g., ALT and AST), decarboxylation reactions, glycogen phosphorylase.
- Synthesis of glutathione, cystathionine, heme, niacin, histamine, and neurotransmitters including serotonin, epinephrine, norepinephrine (NE), dopamine, and GABA.
- Deficiency
- Convulsions, hyperirritability, peripheral neuropathy (deficiency inducible by isoniazid and oral contraceptives), sideroblastic anemia (due to impaired hemoglobin synthesis and iron excess).
- Co-enzyme in the metabolism of amino acids, glycogen, and sphingolipids
- Antioxidant effects
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