Neuropathic meds

Line of therapy	Class	Drugs	Dose range	Adverse effects
First‑line	Gabapentinoids	Gabapentin	150–600 mg/day	Lethargy, vertigo, peripheral swelling, blurred vision
First‑line	Gabapentinoids	Pregabalin	300–3600 mg/day	Lethargy, vertigo, peripheral swelling, increased body weight
First‑line	Tricyclic antidepressants (TCAs)	Amitriptyline	10–150 mg/day	Anticholinergic effects, QT prolongation (arrhythmia), suicide risk, urinary retention
First‑line	Serotonin–norepinephrine reuptake inhibitors (SNRI)	Duloxetine	20–120 mg/day	Nausea, lethargy, constipation, ataxia, dry mouth
First‑line	Serotonin–norepinephrine reuptake inhibitors (SNRI)	Venlafaxine	150–225 mg/day	Nausea, vertigo, lethargy, hyperhidrosis, hypertension
Second‑line	Opioids	Tramadol	25–400 mg/day	Nausea/vomiting, constipation, lethargy, seizures, ataxia
Second‑line	Opioids	Tapentadol	50–600 mg/day	Nausea/vomiting, constipation, lethargy, seizures, ataxia
Second‑line	Topical treatment	Lidocaine	5% patches or gel	Local erythema, itching, rash
Second‑line	Topical treatment	Capsaicin	8% patches	Pain, erythema, itching; rare cases of high blood pressure
Third‑line	Strong opioids	Morphine	10–120 mg/day	Nausea, vomiting, constipation, dizziness, lethargy
Third‑line	Strong opioids	Oxycodone	10–120 mg/day	Nausea/vomiting, constipation, lethargy, respiratory control issues
Third‑line	Neurotoxin	Botulinum toxin	25–300 U BTX‑A 0.9% saline	Pain at injection site

No result found