Blood products

Difference between PCC and FFP

Parameter	PCC	FFP
Feasibility – ease of use	+++	+
Cost-effectiveness	+++	+
Volume loading	Loads less volume	Loads more volume
Onset of efficacy	Sooner	Later
INR reversal	More rapid	ㅤ
Time taken for completion of treatment	More rapid	ㅤ
Cardiopulmonary adverse effects	None	ㅤ

Product	Component(s)	Volume
Packed red blood cells (pRBC)	RBCs	1 unit = 300 mL
Single donor platelets (SDP)	Platelets	1 pack = 6 units = 300 mL
Fresh frozen plasma (FFP)	Factors II, VII, VIII, IX, X, XI	1 unit = 250–300 mL
Prothrombin complex concentrate (4‑factor PCC / Kcentra)*	Factors II, VII, IX, X, proteins C & S	1000 units = 40 mL - Empiric = 1500–2000 units - INR 2–4 = 25 units/kg - INR 4–6 = 35 units/kg - INR >6 = 50 units/kg
Cryoprecipitate	Factors VIII, XIII, fibrinogen, von Willebrand factor (vWF)	1 unit = 10–15 mL - 1 unit increases fibrinogen by ~7–10 mg/dL in a 70kg patient - Typical dose ≈10 units with a target fibrinogen ≥100–150 mg/dL

*3‑factor PCC lacks factor VII and proteins C & S; it is mainly used for bleeding in haemophilia B and is still rarely used compared with targeted factor IX replacement or 4‑factor PCC.