QT prolongation

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  • Specific treatment of hypokalemia, hypomagnesemia, and medication toxicity may correct a prolonged QT interval. Antiarrhythmic (e.g. quinidine, sotalol, amiodarone) or antipsychotic drugs (e.g. haloperidol) known to affect the QT interval should be avoided in these patients, especially if their neurologic injury exacerbates underlying hereditary long QT syndrome.
  • Drug-induced long QT (ABCDEF+NO)
    • A: anti-Arrhythmics (Ia and III), Arsenic
    • B: anti-Biotics (macrolides, fluoroquinolones)
    • C: anti-Cychotics (haloperidol), Chloroquine
    • D: anti-Depressants (TCAs), Diuretics (thiazides)
    • E: anti-Emetics (ondansetron)
    • F: anti-Fungals (Fluconazole)
    • N: Navir (protease inhibitors)
    • O: Opioids (methadone)