- Psychiatric disorders are highly heterogeneous conditions that affect multiple overlapping circuits → target selection hard
Depression
- Targets
- Brodmann area 25 in the subgenual cingulate cortex (SCC) - most used
- Anterior limb of the capsula interna (ALIC)
- Ventral caudate
- Lateral habenula
- Superolateral branch of the medial forebrain bundle (slMFB)
Alzheimer
- Targets for dementias
- Fornix for Alzheimer’s disease,
- Nucleus basalis of Meynert (substantia innominata) for dementia with Lewy bodies.
OCD
- 1/3 of patients do not respond to standard, guideline- concordant care and are eligible for neuromodulation
- Target
- Anterior limb of the internal capsule
- Nucleus accumbens
- Ventral capsule/ventral striatum
- STN
- Inferior thalamic peduncle
Bipolar
- Targets
- Subgenual cingulate cortex (SCC)
- Nucleus accumbens
- slMFB
Anorexia nervosa
- Physical manifestations: severe emaciation and malnourishment
- Targets
- Subgenual cingulate cortex (SCC)
- Nucleus accumbens
Tourette syndrome
- Hard to treatment:
- Complexity of symptoms, consisting of a variety of tics and psychiatric disturbances, such as personality disorders, anxiety, depression, substance abuse and many others
- Hence has uncertain target
- Centromedian nucleus-parafascicular complex of thalamus
- Basal ganglia sub territories
Made with Bullet