Grade 5 osteotomy

General

  • Resection of 1 vertebrae is Grade 5
  • Resection of >1 vertebrae is Grade 6

Indication

  • Treatment of sharp, angular, rigid kyphotic deformity in TL and T spine
    • >90 degree cobb
    • <25% improvement on bending
  • Resection of hemivertebrae
  • Post infection deformity
  • Intravertebral bony spinal tumors resection
  • Tethered cord
    • The shortening of the spine proximal to a tethered region as a novel method of treating tethered spinal cord without the risks of dissection around adhesed nerve roots.

Pre-op

  • Get CT
    • Study pedicle anatomy
    • Identify regions with
      • Ankylosis or fusion
      • Pseudoarthrosis (if had previous surgery)
    • Planning of osteotomies
    • Complex anatomy

Surgical principles

Anatomical resection
Suk technique
  • Resection
    • All posterior elements
    • Facet joints at the levels above and below
    • Entire VB
    • Supra-adjacent/ subjacent discs.
  • Spine is then disarticulated, and the proximal and distal limbs are slowly brought together.
  • Anterior fusion is performed with structural support via an anterior cage
    • This allows for relative anterior lengthening, through the use of an expandable cage implant, which enhances the degree of correction.
Kawahara technique: A closing-opening wedge osteotomy
  • A kyphotic deformity is reduced by resection of the vertebra through a costotransverse approach → “closing” of the gap with posterior compression → “opening” of the anterior column with cage insertion.

Positioning

  • Aim
    • Adequate exposure to the surgical site.
    • Passive spinal column correction.
    • Minimise the risk of associated pressure-related injuries to the patient.
  • Common Positions and Historical Context:
    • Prone most common
      • Historical descriptions of the prone position, such as the "tuck, knee-chest, and praying position," were associated with high rates of complications.
        • Vascular injury
        • Peripheral nerve injury
        • Muscle necrosis → acute kidney injury
    • Other position Supine and lateral
  • Advancements in Positioning Equipment:
    • Modern frames
      • has significantly reduced complications.
      • Designed to:
        • Pad bony prominences.
        • Maintain physiological positioning of the limbs.
        • Reduce intra-abdominal and intra-ocular pressure.
        • Play a vital role in inducing lordosis or kyphosis on the native spine, depending on surgical goals.
      • Studies on frame impact:
        • Hastings, Andrews, and four-poster frames were reported to cause a 50% reduction in overall lumbar lordosis compared to preoperative standing alignment.
        • OSI Jackson surgical table
            • Introduced in 1992
            • Has ability to generate lordosis.
            • A dual-column design, allowing for an
              • Unrestricted abdomen
              • 360 degrees of rotation
              • Complete radiolucency
              •  
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  • Leg positioning
    • Influences spinal lordosis and kyphosis
      • Placing legs in a sling allows for relative hip flexion, which can facilitate decreasing lumbar lordosis.
      • Placing legs on flat boards with pillows will extend the hips, thereby inducing lumbar lordosis.
  • Risks and Complications of Improper Patient Positioning:
    • Perioperative Peripheral Nerve Injury (PPNI):

      • Risk of peripheral nerve damage:
        • Patient factors
          • Medical conditions – diabetes, smoking, high blood pressure, vascular disease.
          • Being male.
          • Increasing age.
          • Being very overweight or extremely thin.
        • Surgical factors
          • More complicated operations which involve more instruments are more likely to damage nerves than simpler operations.
          • Certain operations, including:
            • Operations on the spine or brain
            • Cardiac or vascular operations (on the heart or major blood vessels)
            • Operations on the neck or parotid (a gland in the face)
            • Some kinds of breast operation
            • Operations in which a tourniquet (a tight band around a limb) is used to reduce bleeding.
          • Positioning
            • Prone
            • Lateral
      • Typically presents as
        • Neuropraxia or
        • Axonotmesis.
      • Lower Extremity Injuries:
        • Patients with significant fixed sagittal malalignment can sustain various lower extremity nerve compressions, such
          • As quadriceps palsy, even with appropriate padding, which can be relieved by appropriate recognition and interventions.
      • Upper Extremity Injuries:
        • Brachial Plexus
          • Highly susceptible to stretch injuries due to its fixation at the cervical and axillary fascia and its traversal through bony architecture (clavicle, first rib, humeral head).
          • Risk factor
            • Abduction of the arm greater than 90° (Greatest risk)
            • Extension, external rotation plus abduction of the arm
            • Rotation plus lateral flexion of the neck in the ipsilateral direction
            • Application of shoulder braces.
        • The most common clinical presentation is a motor deficit, with the majority of cases resolving over time.
      • Specific Peripheral Neuropathies:
        • Ulnar nerve palsy
          • Increased risk with
            • Elbow flexion greater than 90°
              • Most vulnerable peripheral nerve in the upper extremity to brachial artery ischemia.
            • Direct pressure to the cubital tunnel
              • Obesity and preoperative cubital tunnel syndrome are identified risk factors for ulnar nerve injury.
            • Malpositioning of a blood pressure cuff
        • Lateral femoral cutaneous neuropathy (meralgia paresthetica)
          • Reported in up to 24% of patients undergoing prone spinal surgery.
          • This is believed to be caused by direct compression of the nerve by the pelvic bolsters near the anterior superior iliac spine.

      Post-Operative Vision Loss (POVL):

      • Occurs in 0.03%.
      • Due to
        • Ischemic optic neuropathy
        • Central artery occlusion
        • Ischemic orbital compartment syndrome
        • Occipital cerebral infarction.
      • Proposed pathogenesis involves increased orbital venous and intraocular pressure due to external pressure during surgery.
      • Risk factors include:
        • Prolonged operative time.
        • Intraoperative anaemia.
        • Hypotension.
        • High-volume infusions.
        • Trendelenburg position.
        • Rotation of the head.
        • Applied ventral pressure, which may compromise blood flow to the optic nerve.
      • Mitigation strategies:
        • Routine use of a skull clamp
          • (e.g., Gardner-Wells tongs, halo, or Mayfield)
          • For long-segment spinal deformity surgery in some institutions.
          • Pros
            • Not applying external pressure to the orbit compared to horseshoe and foam headrests.
            • Unobstructed visualisation of the face
            • Controlled positioning of the cervical spine
            • Facilitate surgical exposure.
Technical Considerations for VCR:
  • Rib Resection:
    • Thoracic VCRs may necessitate unilateral or bilateral resection of ribs (typically 5 cm) and transverse processes to expose the lateral vertebral body.
  • Nerve Root Management:
    • Nerve roots on the convexity are clamped for 5 minutes with continuous neuromonitoring before ligation; the concave root may be preserved.
  • Spinal Stabilization:
    • The spine should be stabilised with a temporary rod fixed to pedicle screws at least 3 segments above and below the VCR site;
    • dual stabilization rods are recommended for severe kyphosis.
    • Hooks can be used for stability and correction in fused segments.
  • Corpectomy:
    • The vertebral body is often rotated laterally and dorsally on the convexity to facilitate bony corpectomy. The concave pedicle is removed carefully, potentially after spinal shortening via convex compression to relieve neural tension.
  • Posterior Wall Removal:
    • The posterior wall is removed last to minimise epidural bleeding and protect the spinal cord.
    • A thin portion of the anterior vertebral body can be left intact to promote fusion.
  • Correction Maneuvers:
    • Involve shortening and translation of the vertebral column, achieved through direct compression or construct-to-construct compression.
  • Spinal Cord Monitoring:
    • TIVA for IOM
    • The spinal cord must be constantly monitored for stretch or buckling during correction.
  • Anterior Cage Placement:
    • An anterior cage is placed to restore anterior column support, serve as a fulcrum for kyphosis correction, and prevent excessive shortening and spinal cord buckling.
  • Final Rods and Fusion:
    • After correction, the contralateral final rod and additional support rods are inserted. Structural allograft or autograft may be placed dorsally over the laminectomy site to protect neural elements and facilitate fusion.
 
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Outcome

Degree of correction
  • Suk's series (70 patients):
    • 61.9% coronal correction,
    • 47.5° sagittal correction,
    • 2.53 cm coronal balance restoration,
    • 2.77 cm sagittal balance restoration.
  • Lenke et al. (North American series):
    • Correction rates of 69% for severe scoliosis,
    • 54% for global kyphosis,
    • 63% for angular kyphosis,
    • 54% for kyphoscoliosis.
  • Lenke et al. (largest paediatric series):
    • 54% improvement in the coronal plane
    • 47% improvement in the sagittal plane.
  • No difference in complication rates was found between posterior-only VCR (pVCR) and circumferentially performed VCR, or between staged and single-stage VCR procedures.
Bianco 2014
  • for all 3 column osteotomies Grade 3-6 osteotomies
    • Op time 456.9 minutes
    • 42% overall complications
      • Intraoperative complications
        • Complication
          Incidence
          Cardiac arrest
          0.2%
          Spinal cord deficit
          2.6%
          Death
          0.0%
          Nerve root injury
          1.4%
          Optic deficit/blindness
          0.0%
          Vessel/organ injury
          1.7%
          Pneumothorax
          1.2%
          Unplanned staged surgery
          1.4%
           
      • Post-operative complications
        • Complication
          Incidence
          Bowel/bladder dysfunction
          6.9%
          Death
          0.2%
          DVT
          3.1%
          Cauda equina syndrome
          0.5%
          Deep infection
          7.6%
          Motor deficit or paralysis
          12.1%
          Myocardial infarction
          0.5%
          Visual deficit/blindness
          0.5%
          Pneumonia
          2.8%
          PE
          2.8%
          Reintubation
          1.2%
          Sepsis
          0.7%
          Stroke
          0.5%
          ARDS
          4.7%
          Pancreatitis
          0.0%
          Unplanned return to OR
          19.4%
          Tracheotomy
          0.2%
          Arrhythmia
          1.2%
          Major injury to vessel requiring repair
          0.3%
          Hemopneumothorax
          0.7%
       
Qiao 2018
  • More complications in the kyphoscoliosis group (30.3%) vs kyphosis group (18.2%)
  • No difference in neurological complication rates
Wang 2016
  • For posterior vertebral column resection (PVCR).
  • Calculation: (Total Deformity angular ratio) T DAR = S DAR + C DAR
    • (Sagittal) S DAR
      • Maximum kyphotic angle divided by the number of vertebral levels involved
    • (Coronal) C DAR
      • Cobb angle of the maximum scoliosis curve divided by the number of vertebral levels involved
  • High total DAR (≥25)
    • More Pre op myelopathic (33.3% vs. 11.7%, P = 0.000)
    • Needed larger vertebral resections (1.8 vs. 1.3, P = 0.000),
    • Significantly higher rate of IOM events than seen in the low total DAR (<25) patients (41.1% vs. 10.8%; P = 0.000).
  • High sagittal DAR (≥15)
    • Higher rate of SCM events (34.0% vs. 15.1%, P = 0.005)
    • Greater chance of neurologic deficits postoperatively (12.5% vs. 0, P = 0.000).

Complication

  • 78% at least 1 complication
    • 61% major complication
  • Posterior-only VCRs
    • Reduced operative time (from 12 hrs)
      • Suk 2002 reported mean operative time of 4.5 hours
    • Reduced perioperative bleeding (5L)
      • Suk 2002 reported mean EBL of 2333 mL.
      • Reducing blood loss
        • Anti-fibrinolytic agents: aprotinin, TXA
        • Hypotensive anesthesia during exposure
        • Intrathecal Opioids
        • Discectomy before vertebrectomy
        • Meticulous haemostasis
        • Cell saver
  • Surgical Site Infection (SSI):
    • VCRs
      • Overall SSI rate of 11.1%.
        • Rates of SSI requiring return to the operating room range from 3% to 9%.
      • Higher risk of deep SSI (9.7%) compared to PSO (3.4%) and PCO (1.5%)
  • Neurologic Complications:
    • Changes in intraoperative neuromonitoring are common (in roughly 1 in 4 cases), with most being correctable.
    • The risk of permanent neurologic complication (either root or spinal cord) ranges from 2% to 6%.
    • Risk factors
      • greatest pre-existing neurological dysfunction
      • Intraspinal and brainstem anomalies
      • Scoliosis + hyperkyphosis
    • Prevention
      • Spinal cord impact
      • Shortening or redundancy of spinal cord
        • Qiu-an 2019:
          • Safe to shorten spinal cord to 1/2-1/4 of body height + adjacent disc
          • Any more can lead to kinking and reduction of blood flow
      • Maintain BP >90/60mmHg during vertebrectomy
    • Pseudoarthrosis
      • Avoiding by
        • Satellite or accessory rods
        • Always reinforce with a bone graft
    • Infection
      • Higher risk for deep infection: Albert 2010
        • PVCR 9.7%
        • PSO 3.4%
        • PCO 1.5%
      • Due to wider exposure to perform PVCR
      • Avoid by multiple layer closure
    • 11% Dural tear

Alternatives to PVCR