Technetium-99m

  • Technetium agents based on the technetium-99m (Tc-99m) radioisotope are frequently used agents in medical imaging.
  • A radiopharmaceutical labelled with Tc-99m constitutes a co-ordination complex in which ligands bond to a central atom of Tc-99m by co-ordinate covalent bonds
  • Radioactive technetium radiotracer can be chelated to a number of different compounds to create specific radiopharmaceuticals
    • Tc-99m HMPAO labelled WBC: infection scintigraphy
      • High false positive rate for infection
      • Early diagnosis of pyogenic vertebral osteomyelitis because it demonstrates positive findings before X-ray changes
    • Tc-99m HMPAO (hexamethylpropyleneamine oxime)
    • Technetium-99m ECD: CNS imaging
    • Technetium-99m GHA
      • Oncological imaging (e.g. low-grade glioma, lung)