- Pressure gradient across the cerebral vascular bed, between blood inflow and outflow.
- Inflow pressure is taken as mean arterial pressure (MAP),
- Calibrated to the level of the right atrium of the heart.
- Outflow or downstream pressure is the jugular venous pressure (JVP),
- Calibrated to the level of the right atrium
- Management of severe TBI patients using guidelines-based recommendations for CPP monitoring is recommended to decrease 2-week mortality.
- Gerber 2013:
- Significant decrease in mortality appears to be associated with increase in adherence to guidelines, particularly management guided ICP and CPP monitoring
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