- Hyperglycaemia exacerbates secondary neuronal injury and is associated with worsened outcomes after severe TBI.
- Vespa et al., 2012: ‘Tight’ glycaemic control with intensive insulin therapy can precipitate cerebral hypoglycaemia and metabolic crises after TBI
- Kramer 2012: Moderate serum glucose control is therefore recommended, maintaining serum glucose concentration between 7 and 10 mmol/ litre, and avoiding hypoglycaemia (serum glucose <4.4 mmol/ litre) and large swings in glucose concentration.
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