Definition
- A tauopathy that develops slowly over years before symptoms appear after neurotrauma.
Pathology
- Neurofibrillary tangles in specific brain areas
- Amyloid and TDP-43 protein accumulations.
Clinical features
- Variable age of onset
- Variable behavioural, mood, and cognitive deficits present at the time of death
- (92% symptomatic at time of death).
- Potential for increased risk and accelerated development of Alzheimer's disease and motor neuron disease
- Can only be diagnosed post mortem with a pathology-confirmed analysis.
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