- 2nd brain injury
- Duration
- Minutes to weeks
- Treatment of secondary injuries is essential to maximizing patient outcome.
- International Mission for Prognosis and Clinical Trials in TBI (IMPACT) database identified hypoxia and hypotension to be present in 20% and 18% of TBI patients, respectively
- 5 variables that are correlated with morbidity and poor outcome:
- Arterial hypotension,
- Reduced CPP,
- Elevated ICP
- Hypoxemia
- Pyrexia
- Pathophysiology
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