Sub group
- Have characteristics associated with the embryonic stage of development (e.g. the pluripotent nature of teratomas)
- Embryonic (within a foetus)
- Teratoma (19.6%)
- Mature (63.3%)
- Immature (23.3%)
- Exhibiting malignant transformation (13.3%)
- Embryonal carcinoma (3.3%)
- Extra-embryonic (outside of foetus)
- Yolk sac tumour (2%)
- Choriocarcinoma (2%)
- Mixed germ cell tumours (32%)
- Neoplasms harbouring multiple types
Histopathology
- Microscopic
- Contain cytokeratin structural proteins, indicating epithelial cell lineage, a major histopathological differentiating factor between the two major GCT types.
- Have characteristics associated with the embryonic stage of development (e.g. the pluripotent nature of teratomas)
Localisation
- Non-germinomatous
- Pineal region
- Suprasellar compartment, either simultaneously or sequentially.
- Bilateral basal ganglionic and thalamic lesions are also well recognized.
Immunophenotype
- +
- Cytokeratin structural proteins
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