Neurosurgery notes/Tumours/Mesenchymal non meningothelial tumours/Soft tissue tumors

Soft tissue tumors

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Parent item
Mesenchymal non meningothelial tumours
Sub-item
Solitary fibrous tumour (SFT)
Hemangiomas and vascular malformations
Haemangioblastoma
Ewing sarcoma
Rhabdomyosarcoma
Intracranial mesenchymal tumor, FET-CREB fusion-positive
CIC-rearranged sarcoma
Primary intracranial sarcoma, DICER1-mutant

Consist of

  • Soft tissue tumors
    • Fibroblastic and myofibroblastic tumors
      • Solitary fibrous tumor
    • Vascular tumors
      • Hemangiomas and vascular malformations
      • Hemangioblastoma
    • Skeletal muscle tumors
      • Rhabdomyosarcoma
    • Uncertain differentiation
      • Intracranial mesenchymal tumor, FET-CREB fusion-positive
      • CIC-rearranged sarcoma
      • Primary intracranial sarcoma, DICER1-mutant
      • Ewing sarcoma
Newly recognized mesenchymal, non-meningothelial tumors of uncertain histogenesis. (A) Intracranial mesenchymal tumor, FET-CREB fusion-positive (H&E, ×200); these tumors have variable morphology and a fusion of an FET RNA-binding protein family gene and a member of the CREB family of transcription factors. (B, C) CIC-rearranged sarcoma, with (B) poorly differentiated cells (H&E, ×200) and (C) with ETV4 frequently being upregulated in these tumors (×200). (D) Primary intracranial sarcoma, DICER1-mutant with characteristic eosinophilic cytoplasmic droplets (H&E, ×200).
Newly recognized mesenchymal, non-meningothelial tumors of uncertain histogenesis. (A) Intracranial mesenchymal tumor, FET-CREB fusion-positive (H&E, ×200); these tumors have variable morphology and a fusion of an FET RNA-binding protein family gene and a member of the CREB family of transcription factors. (B, C) CIC-rearranged sarcoma, with (B) poorly differentiated cells (H&E, ×200) and (C) with ETV4 frequently being upregulated in these tumors (×200). (D) Primary intracranial sarcoma, DICER1-mutant with characteristic eosinophilic cytoplasmic droplets (H&E, ×200).