Summary
Tumor Type | Genes/Molecular Profiles Characteristically Altered |
Astrocytoma, IDH-mutant | IDH1, IDH2, ATRX, TP53, CDKN2A/B |
Oligodendroglioma, IDH-mutant, and 1p/19q-codeleted | IDH1, IDH2, 1p/19q, TERT promoter, CIC, FUBP1, NOTCH1 |
Glioblastoma, IDH-wildtype | IDH-wildtype, TERT promoter, chromosomes 7/10, EGFR |
Diffuse astrocytoma, MYB- or MYBL1-altered | MYB, MYBL1 |
Angiocentric glioma | MYB |
Polymorphous low-grade neuroepithelial tumor of the young | BRAF, FGFR family |
Diffuse low-grade glioma, MAPK pathway-altered | FGFR1, BRAF |
Diffuse midline glioma, H3 K27-altered | H3 K27, TP53, ACVR1, PDGFRA, EGFR, EZHIP |
Diffuse hemispheric glioma, H3 G34-mutant | H3 G34, TP53, ATRX |
Diffuse pediatric-type high-grade glioma, H3-wildtype, and IDH-wildtype | IDH-wildtype, H3-wildtype, PDGFRA, MYCN, EGFR (methylome) |
Infant-type hemispheric glioma | NTRK family, ALK, ROS, MET |
Pilocytic astrocytoma | KIAA1549-BRAF, BRAF, NF1 |
High-grade astrocytoma with piloid features | BRAF, NF1, ATRX, CDKN2A/B (methylome) |
Pleomorphic xanthoastrocytoma | BRAF, CDKN2A/B |
Anaplastic ganglioglioma | BRAF, CDKN2A/B |
Choroid glioma | PRKCA |
Astroblastoma, MN1-altered | MN1 |
Ependymoma | BRAF |
Dysplastic neuroepithelial tumor | FGFR1 |
Diffuse glioneuronal tumor with oligodendroglioma-like features and nuclear clusters | Chromosome 14, (methylome) |
Papillary glioneuronal tumor | PRKCA |
Rosette-forming glioneuronal tumor | FGFR1, PIK3CA, NF1 |
Myxoid glioneuronal tumor | PDGFRA |
Diffuse leptomeningeal glioneuronal tumor | KIAA1549-BRAF fusion, 1p (methylome) |
Multinodular and vacuolating neuronal tumor | MAPK pathway |
Dysplastic cerebellar gangliocytoma (Lhermitte-Duclos disease) | PTEN |
Extraventricular neurocytoma | FGFR (FGFR1-TACC1 fusion), IDH-wildtype |
Supratentorial ependymomas | ZFTA, RELA, YAP1, MAML2 |
Posterior fossa ependymomas | H3 K27me3, EZHIP (methylome) |
Spinal ependymomas | NF2, MYCN |
Medulloblastoma, WNT-activated | CTNNB1, APC |
Medulloblastoma, SHH-activated | TP53, PTCH1, SUFU, SMO, MYCN, GLI2 (methylome) |
Medulloblastoma, non-WNT/non-SHH | MYC, MYCN, PRDM6, KDM6A (methylome) |
Atypical teratoid/rhabdoid tumor | SMARCB1 loss, SMARCA4 loss |
Embryonal tumor with multilayered rosettes | C19MC, DICER1 |
CNS neuroblastoma, FOXR2-activated | FOXR2 |
CNS tumor with BCOR internal tandem duplication | BCOR |
Desmoplastic myxoid tumor of the pineal region, SMARCB1-mutant | SMARCB1 |
Meningiomas | NF2, AKT1, TERT, SMO, PIK3CA; KLF4, SMARCE1 |
Adamantinomatous craniopharyngioma | CTNNB1 |
Papillary craniopharyngioma | BRAF |
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