Structural changes
- +7/-10 chromosome copy number changes
- Gain of chromosome 7 usually reflects polysomy or arm‑level gain, while loss of chromosome 10 is typically whole‑chromosome or broad arm‑level loss rather than focal events.
Clinical significance
- copy‑number signature of adult IDH‑wildtype glioblastoma and can be sufficient, together with IDH‑WT/H3‑WT status, to establish this diagnosis in the 2021 WHO CNS classification.
Made with Bullet