- Oncogene encoding a tyrosine kinase resulting in increased DNA synthesis
- Focal high-level copy number gains of the EGFR gene
- Not just Low-level EGFR copy number gains, e.g. trisomy 7, are not sufficient to qualify a tumour as EGFR-amplified.
- Has excellent specificity for gliomas with aggressive behaviour
- Not present in other glioma subtypes that display a more indolent clinical course
- Testing
- Immunohistochemisty for EGFR protein does not provide adequate specificity for detecting EGFR amplification and should not be used to direct clinical care in this setting
- EGFRvIIIa target for GBM vaccine
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