Function
- Encodes a transmembrane protein that functions in multiple developmental processes and the interactions between adjacent cells
Pathological
- Wang 2025
- Recent reviews highlight NOTCH1 as a central hub in oncogenic crosstalk (Wnt/β‑catenin, PI3K/AKT, NF‑κB, Hedgehog, TGF‑β) that sustains glioma growth, treatment resistance, and glioma stem cell maintenance.
- Zhang 2011
- High NOTCH1 expression in glioma tissue correlates with higher tumour grade and poorer overall survival, indicating that NOTCH1 is an adverse prognostic marker.
- NOTCH1 signaling enhances invasion, self‑renewal, and maintenance of glioma‑initiating cells, linking NOTCH1 to stem‑like behaviour and tumour aggressiveness.
- Li 2011
- NOTCH1 protein overexpression is an independent prognostic factor in glioma patients, with higher levels associated with shorter survival times.
- Zhu 2018
- In glioblastoma, NOTCH1 is distinctly activated in classical and proneural molecular subtypes and promotes tumour cell proliferation while inhibiting apoptosis.
- Yao 2015
- Experimental interference with NOTCH1 signaling inhibits glioma cell growth in vitro, supporting a driver role for NOTCH1 in tumour progression.
- Jiang 2010
- NOTCH1 is a transmembrane receptor in the Notch signaling pathway that regulates cell fate decisions, proliferation, and differentiation in many tissues.
- In glioma stem cells, NOTCH1 activation contributes to radioresistance, whereas NOTCH1 knockdown or γ-secretase inhibition sensitizes these cells to radiation.
Clinical significance
- Found in oligodendrogliomas
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