- Structure
- A basic helix–loop–helix transcription factor
- Function
- Regulates specification and differentiation of oligodendrocyte and other glial lineages in the central nervous system.
- OLIG2 is encoded by the OLIG2 gene on chromosome 21
- Expressed in neural progenitor cells, oligodendrocyte precursor cells, and many glial tumors, where it serves as a useful nuclear immunohistochemical marker for diffuse gliomas.
- Helps differentiate
- Met vs glial tumour
- Stains positive in
- Glial tumours
- Normal cells
- Oligodendroglioma (stain +ve) vs an extraventricular neurocytoma (stains -ve)
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