- Encodes TP53 (tumour protein 53)
- TP53 is a tumour suppressor that prevents cells from dividing and signals them to undergo apoptosis if they sustain irreparable DNA damage.
- TP53 gene mutations are common in human cancers
- Cause of Li-Fraumeni syndrome
- Testing
- PCR
- IHC staining
- FISH test
- ATRX & TP53 are mutually exclusive of 1p/19q codeletion
- Can be used as confirmatory markers to distinguish astrocytomas from oligodendrogliomas
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